Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM494235
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
2.00±n/a nM
Citation
 Bryan, MC; Gobbi, A; Kiefer, Jr., JR; Kolesnikov, A; Olivero, AG; Drobnick, J; Liang, J; Rajapaksa, N; Ndubaku, C; Feng, J Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US10988478 Publication Date 4/27/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM494235
Synonyms:
N-[6-[4-(2,2- Difluoroethyl)piperazin-1- yl]-2-[(2R)-2-fluoro-3- hydroxy-3-methyl-butyl]-1- oxo-isoindolin-5-yl]-6- methyl-pyrazolo[1,5- a]pyrimidine-3-carboxamide | US10988478, Example 284
Type:
Small organic molecule
Emp. Form.:
C27H32F3N7O3
Mol. Mass.:
559.5833
SMILES:
Cc1cnc2c(cnn2c1)C(=O)Nc1cc2CN(C[C@@H](F)C(C)(C)O)C(=O)c2cc1N1CCN(CC(F)F)CC1 |r|
Structure:
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