Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM449005
Substrate
n/a
Meas. Tech.
cAMP Assay of SSTR2
EC50
0.55±n/a nM
Citation
 Han, S; Kim, SH; Zhu, Y Somatostatin modulators and uses thereof US Patent  US11186590 Publication Date 11/30/2021 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM449005
Synonyms:
4-(4-aminopiperidin-1-yl)-3-(6-fluoro-4-methoxy-1H-1,3-benzodiazol-2-yl)-5-(3-fluoro-5-methylphenyl)pyridine-2-carboxamide | US10696689, Compound 2-3 | US11186590, Compound 2-3
Type:
Small organic molecule
Emp. Form.:
C26H26F2N6O2
Mol. Mass.:
492.5204
SMILES:
COc1cc(F)cc2nc([nH]c12)-c1c(ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: