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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM563502
Substrate
n/a
Meas. Tech.
Inhibition of Tryptophan Hydroxylase Activity
IC50
433±n/a nM
Citation
 Ahn, JH; Kim, H; Suh, J; Lee, I; Kim, K; Park, K; Bae, EJ; Shong, KE; Pagire, SH; Lim, A; Jeon, J; Pagire, HS; Zhang, H; Kim, M; Pyo, J Tryptophan hydroxylase inhibitor and pharmaceutical composition including same US Patent  US11407763 Publication Date 8/9/2022 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM563502
Synonyms:
(2S)-2-amino-3-(4-(2- amino-6-(1-(5-chloro- [1,1'-biphenyl]-2-yl)- 2,2,2- trifluoroethoxy)pyrimidine- 4-yl)cyclohex-3- ene-1-yl)propionic acid hydrochloride | US11407763, Example 48
Type:
Small organic molecule
Emp. Form.:
C27H26ClF3N4O3
Mol. Mass.:
546.969
SMILES:
N[C@@H](CC1CCC(=CC1)c1cc(OC(c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)nc(N)n1)C(O)=O |r,c:6|
Structure:
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