Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide
Ligand
BDBM572177
Substrate
n/a
Meas. Tech.
MCL-1/Noxa BH3 Peptide (MCL-1 Assay)
IC50
0.920±n/a nM
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide
Synonyms:
MCL-1/Noxa BH3 Peptide
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 3 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]
Synonyms:
BCL2L3 | MCL1 | MCL1_HUMAN
Type:
n/a
Mol. Mass.:
17056.39
Organism:
Homo sapiens (Human)
Description:
Q07820[173-321]
Residue:
149
Sequence:
ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
  
Component 2
Name:
Maltose/maltodextrin import ATP-binding protein MalK
Synonyms:
MALK_ECOLI | malK
Type:
Protein
Mol. Mass.:
40990.98
Organism:
n/a
Description:
P68187
Residue:
371
Sequence:
MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV
 
Component 3
Name:
Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V]
Synonyms:
APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa
Type:
Protein
Mol. Mass.:
3072.54
Organism:
Human
Description:
Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide
Residue:
26
Sequence:
PAELEVEVATQLRRFGDKLNFRQKLL
  
Inhibitor
Name:
BDBM572177
Synonyms:
(rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,14-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid | US11447504, Example 30 | US11478451, Example 30
Type:
Small organic molecule
Emp. Form.:
C33H34ClFN4O3
Mol. Mass.:
589.099
SMILES:
CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23
Structure:
Search PDB for entries with ligand similarity: