Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [149-345,G230A,H232R,R293Q]
Ligand
BDBM598368
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR)
Kd
15190±n/a nM
Citation
 Morrow, BJ; Camerino, MA; Walker, SR; Stevenson, GI; Stupple, PA Substituted condensed thiophenes as modulators of sting US Patent  US11613525 Publication Date 3/28/2023 
Target
Name:
Stimulator of interferon genes protein [149-345,G230A,H232R,R293Q]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | TMEM173
Type:
Protein
Mol. Mass.:
22434.40
Organism:
Human
Description:
Q86WV6[149-345,G230A,H232R,R293Q]
Residue:
197
Sequence:
EKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGS
  
Inhibitor
Name:
BDBM598368
Synonyms:
3-((4-carbamoyl-2-fluorophenoxy)methyl)-4-fluorobenzo[b]thiophene-2-carboxylic acid | US11613525, Example 59
Type:
Small organic molecule
Emp. Form.:
C17H11F2NO4S
Mol. Mass.:
363.335
SMILES:
NC(=O)c1ccc(OCc2c(sc3cccc(F)c23)C(O)=O)c(F)c1
Structure:
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