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Target
Transcriptional enhancer factor TEF-5
Ligand
BDBM626330
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
3400±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-5
Synonyms:
DTEF-1 | TEA domain family member 3 | TEAD-3 | TEAD3 | TEAD3_HUMAN | TEAD5 | TEF5 | Transcriptional enhancer factor TEF-5
Type:
PROTEIN
Mol. Mass.:
48683.38
Organism:
Homo sapiens
Description:
ChEMBL_119185
Residue:
435
Sequence:
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
  
Inhibitor
Name:
BDBM626330
Synonyms:
2-[[[4-cyano-7-[4- (trifluoromethyl)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid | US11787775, Compound 15
Type:
Small organic molecule
Emp. Form.:
C20H15F3N2O3
Mol. Mass.:
388.3399
SMILES:
OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)C(F)(F)F
Structure:
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