Reaction Details Report a problem with these data
Target
High affinity nerve growth factor receptor [441-796]
Ligand
BDBM136642
Substrate
n/a
Meas. Tech.
ELISA Assay
pH
7.5±n/a
IC50
1.7±n/a nM
Comments
extracted
Citation
 Haas, J; Andrews, SW; Jiang, Y; Zhang, G Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds US Patent  US9676783 Publication Date 6/13/2017 
Target
Name:
High affinity nerve growth factor receptor [441-796]
Synonyms:
MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A | Tyrosine kinase receptor A (TrkA)
Type:
Protein
Mol. Mass.:
39939.20
Organism:
Homo sapiens (Human)
Description:
Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:
356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM136642
Synonyms:
US10005783, 59 | US10047097, 59 | US10774085, Example 59 | US11267818, Example 59 | US8865698, 59 | US9676783, 59
Type:
Small organic molecule
Emp. Form.:
C22H18F2N6O
Mol. Mass.:
420.4147
SMILES:
Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r|
Structure:
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