Target

Ligand

Substrate

Meas. Tech.

Cathepsin D Enzymatic Assay

pH

4±n/a

Temperature

295.15±n/a K

Citation

 Baxter, EW; Conway, KA; Kennis, L; Bischoff, F; Mercken, MH; Winter, HL; Reynolds, CH; Tounge, BA; Luo, C; Scott, MK; Huang, Y; Braeken, M; Pieters, SM; Berthelot, DJ; Masure, S; Bruinzeel, WD; Jordan, AD; Parker, MH; Boyd, RE; Qu, J; Alexander, RS; Brenneman, DE; Reitz, AB 2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (beta-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead. J Med Chem 50:4261-4 (2007) [PubMed]  Article Copy BDB DOI

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Name:

Cathepsin D

Synonyms:

CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor

Type:

Enzyme

Mol. Mass.:

44551.72

Organism:

Homo sapiens (Human)

Description:

Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.

Residue:

412

Sequence:

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

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Name:

BDBM17786

Synonyms:

(4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-yl)-N,4-dicyclohexyl-N-methylbutanamide | 2-aminoquinazoline, 3a

Type:

Small organic molecule

Emp. Form.:

C31H42N4O2

Mol. Mass.:

502.6908

SMILES:

CN(C1CCCCC1)C(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N |r,c:38|

Structure:

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Similarity to this molecule at least:

Name:

Cathepsin D FRET Substrate

Synonyms:

(7-Methoxycoumarin-4-yl)acetyl-Glycyl-L-Lysyl-L-Prolyl-L-Isoleucyl-L-Leucyl-L-Phenylalanyl-L-Phenylalanyl-L-Arginyl-L-Leucyl-N-(2,4-Dinitrophenyl-L-Lysyl)-D-Arginine Amide

Type:

Peptide

Mol. Mass.:

4565.53

Organism:

n/a

Description:

n/a

Residue:

40

Sequence:

MCACGLYLYSPRILELEPHEPHEARGLELYSDNPDARGNH