Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM19644
Substrate
BDBM19584
Meas. Tech.
Enzyme Inhibition Assay
Ki
267±n/a nM
Citation
 Chatterjee, AK; Liu, H; Tully, DC; Guo, J; Epple, R; Russo, R; Williams, J; Roberts, M; Tuntland, T; Chang, J; Gordon, P; Hollenbeck, T; Tumanut, C; Li, J; Harris, JL Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett 17:2899-903 (2007) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM19644
Synonyms:
(2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo-N-[(2S)-1-{[4-(trifluoromethoxy)phenyl]amino}butan-2-yl]butanamide | succinamide peptidomimetic, 10
Type:
Small organic molecule
Emp. Form.:
C26H38F3N3O4
Mol. Mass.:
513.5928
SMILES:
CC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)CC(=O)N1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19584
Synonyms:
7-amino-3-carbamoylmethyl-4-methyl coumarin labeled fluorescent peptide | Ac-His-Lys-Phe-Lys-ACMC
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: