Reaction Details
Report a problem with these data
![](/images/Email.png)
Target
Gamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-3 [26-473]/gamma-2 [40-467]
Ligand
BDBM25877
Substrate
BDBM25878
Meas. Tech.
Radioligand Binding Assay
Ki
28.8±n/a nM
Citation
![](/images/small/blackdot.gif)
More Info.:
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-3 [26-473]/gamma-2 [40-467]
Synonyms:
GABAA Receptor, alpha-6, beta-3, gamma-2
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
Cell membranes from HEK cells transfected with GABAA beta-3, gamma-2, and alpha-6 were used in binding assays.
Components:
This complex has 3 components.
Component 1
Name:
Gamma-aminobutyric acid receptor subunit gamma-2 [40-467]
Synonyms:
GABA(A) receptor subunit gamma-2 | GABAA Receptor Subunit gamma-2 | GABRG2 | GBRG2_HUMAN | Gamma-aminobutyric acid receptor subunit gamma-2
Type:
Ionic channel
Mol. Mass.:
49862.76
Organism:
Homo sapiens (Human)
Description:
P18507[40-467]
Residue:
428
Sequence:
QKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Component 2
Name:
Gamma-aminobutyric acid receptor subunit beta-3 [26-473]
Synonyms:
GABA(A) receptor subunit beta-3 | GABAA Receptor Subunit beta-3 | GABRB3 | GBRB3_HUMAN | Gamma-aminobutyric acid receptor subunit beta-3
Type:
Ionic channel
Mol. Mass.:
51609.41
Organism:
Homo sapiens (Human)
Description:
P28472[26-473]
Residue:
448
Sequence:
QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
Component 3
Name:
Gamma-aminobutyric acid receptor subunit alpha-6 [20-453]
Synonyms:
GABA(A) receptor subunit alpha-6 | GABAA Receptor Subunit alpha-6 | GABRA6 | GBRA6_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-6
Type:
Ionic channel
Mol. Mass.:
48918.05
Organism:
Homo sapiens (Human)
Description:
Q16445[20-453]
Residue:
434
Sequence:
KLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
Inhibitor
Name:
BDBM25877
Synonyms:
CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H15N3O3
Mol. Mass.:
309.3193
SMILES:
CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)C#C
Substrate
Name:
BDBM25878
Synonyms:
5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one | CHEMBL13280 | Flunitrazepam | [3H]Rohypnol | [3H]flunitrazepam
Type:
radiolabeled ligand
Emp. Form.:
C16H12FN3O3
Mol. Mass.:
313.2832
SMILES:
CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O |c:9|