Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM31278
Substrate
biotinylated p53-derived peptide
Meas. Tech.
p53-MDM2 Binding ELISA
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
>250000±n/a nM
Citation
Stoll, R; Renner, C; Hansen, S; Palme, S; Klein, C; Belling, A; Zeslawski, W; Kamionka, M; Rehm, T; Mühlhahn, P; Schumacher, R; Hesse, F; Kaluza, B; Voelter, W; Engh, RA; Holak, TA Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry 40:336-44 (2001) [PubMed] Article
More Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Inhibitor
Name:
BDBM31278
Synonyms:
Chalcone derivative, E
Type:
Small organic molecule
Emp. Form.:
C24H26ClNO5
Mol. Mass.:
443.92
SMILES:
CCOC(=O)C(C)(C)Oc1ccc(CCNC(=O)\C=C\C(=O)c2ccc(Cl)cc2)cc1
Substrate
Name:
biotinylated p53-derived peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1500.70
Organism:
n/a
Description:
n/a
Residue:
11
Sequence:
MPRFMDYWEDL