Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM401017
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
3.50±n/a nM
Citation
 Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity US Patent  US10004755 Publication Date 6/26/2018 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM401017
Synonyms:
US10004755, Compound UNC4291A
Type:
Small organic molecule
Emp. Form.:
C27H38N6O
Mol. Mass.:
462.6302
SMILES:
CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCN(C)CC1 |r,wD:15.15,(-7.14,-3.77,;-5.81,-3,;-4.47,-3.77,;-3.14,-3,;-1.81,-3.77,;-.47,-3,;-.47,-1.46,;.86,-.69,;2.2,-1.46,;3.66,-.99,;4.57,-2.23,;3.66,-3.48,;4.06,-4.96,;5.55,-5.36,;5.94,-6.85,;4.86,-7.94,;5.25,-9.43,;3.37,-7.54,;2.97,-6.05,;2.2,-3,;.86,-3.77,;4.06,.5,;5.55,.9,;5.94,2.39,;4.86,3.48,;3.37,3.08,;2.97,1.59,;5.25,4.96,;6.74,5.36,;7.14,6.85,;6.05,7.94,;6.45,9.43,;4.56,7.54,;4.17,6.05,)|
Structure:
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