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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33142
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
17850±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33142
Synonyms:
MLS000375030 | N-[3-(4-chloroanilino)-1,4-diketo-2-naphthyl]benzamide | N-[3-(4-chloroanilino)-1,4-dioxo-2-naphthalenyl]benzamide | N-[3-(4-chloroanilino)-1,4-dioxonaphthalen-2-yl]benzamide | N-[3-[(4-chlorophenyl)amino]-1,4-bis(oxidanylidene)naphthalen-2-yl]benzamide | SMR000254383 | cid_4112523
Type:
Small organic molecule
Emp. Form.:
C23H15ClN2O3
Mol. Mass.:
402.83
SMILES:
Clc1ccc(NC2=C(NC(=O)c3ccccc3)C(=O)c3ccccc3C2=O)cc1 |c:6|
Structure:
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