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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM46022
Substrate
n/a
Meas. Tech.
SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay
IC50
5980±n/a nM
Citation
 PubChem, PC SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Human
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM46022
Synonyms:
1-(3,4-dihydroxyphenyl)-2-[1-(4-fluorophenyl)tetrazol-5-yl]sulfanylethanone | 1-(3,4-dihydroxyphenyl)-2-[[1-(4-fluorophenyl)-5-tetrazolyl]thio]ethanone | 1-(3,4-dihydroxyphenyl)-2-[[1-(4-fluorophenyl)tetrazol-5-yl]thio]ethanone | 1-[3,4-bis(oxidanyl)phenyl]-2-[[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanone | MLS-0238024.0001 | cid_713665
Type:
Small organic molecule
Emp. Form.:
C15H11FN4O3S
Mol. Mass.:
346.336
SMILES:
Oc1ccc(cc1O)C(=O)CSc1nnnn1-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: