Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM55687
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
2730±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM55687
Synonyms:
MLS000679820 | N-(2-methoxy-4-{[(2-nitrophenoxy)acetyl]amino}phenyl)-2-thiophenecarboxamide | N-[2-methoxy-4-[2-(2-nitrophenoxy)ethanoylamino]phenyl]thiophene-2-carboxamide | N-[2-methoxy-4-[[2-(2-nitrophenoxy)-1-oxoethyl]amino]phenyl]-2-thiophenecarboxamide | N-[2-methoxy-4-[[2-(2-nitrophenoxy)acetyl]amino]phenyl]thiophene-2-carboxamide | SMR000296671 | cid_2237020
Type:
Small organic molecule
Emp. Form.:
C20H17N3O6S
Mol. Mass.:
427.43
SMILES:
COc1cc(NC(=O)COc2ccccc2[N+]([O-])=O)ccc1NC(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: