Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM61368
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
3510±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM61368
Synonyms:
(4S)-1-benzyl-2-(4-hydroxybutylamino)-6-methyl-4-phenethyl-4H-pyrimidine-5-carboxylic acid methyl ester | (4S)-2-(4-hydroxybutylamino)-6-methyl-4-(2-phenylethyl)-1-(phenylmethyl)-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829926 | SMR000672087 | cid_24789246 | methyl (4S)-1-benzyl-2-(4-hydroxybutylamino)-6-methyl-4-(2-phenylethyl)-4H-pyrimidine-5-carboxylate | methyl (4S)-6-methyl-2-(4-oxidanylbutylamino)-4-(2-phenylethyl)-1-(phenylmethyl)-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H33N3O3
Mol. Mass.:
435.5585
SMILES:
COC(=O)C1=C(C)N(Cc2ccccc2)C(NCCCCO)=N[C@H]1CCc1ccccc1 |c:4,22|
Structure:
