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Target
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Ligand
BDBM50254221
Substrate
n/a
Meas. Tech.
ChEBML_1686210
IC50
18000±n/a nM
Citation
 Qi, XY; Cao, Y; Li, YL; Mo, MG; Zhou, L; Ye, DY Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine. Bioorg Med Chem Lett 27:3511-3515 (2017) [PubMed]  Article 
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Synonyms:
SGMS2 | SMS2 | SMS2_HUMAN | Sphingomyelin synthase 2
Type:
PROTEIN
Mol. Mass.:
42294.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108027
Residue:
365
Sequence:
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
  
Inhibitor
Name:
BDBM50254221
Synonyms:
CHEMBL4093369
Type:
Small organic molecule
Emp. Form.:
C20H16N2O2
Mol. Mass.:
316.3532
SMILES:
Cc1cccc(COc2ccccc2-c2nc3cccnc3o2)c1
Structure:
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