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Target
G-protein coupled receptor 4
Ligand
BDBM50260331
Substrate
n/a
Meas. Tech.
ChEBML_1693532
IC50
1590±n/a nM
Citation
 Miltz, W; Velcicky, J; Dawson, J; Littlewood-Evans, A; Ludwig, MG; Seuwen, K; Feifel, R; Oberhauser, B; Meyer, A; Gabriel, D; Nash, M; Loetscher, P Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorg Med Chem 25:4512-4525 (2017) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 4
Synonyms:
G-protein coupled receptor 4 | GPR4_RAT | Gpr4
Type:
PROTEIN
Mol. Mass.:
41280.26
Organism:
Rattus norvegicus
Description:
ChEMBL_117555
Residue:
365
Sequence:
MDNSTGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVRQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYSNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMERWVAWMNLYRVFVGFLFPWALMLLCYRGILRAVQSSVSTERQEKVKIKRLALSLIAIVLVCFAPYHALLLSRSAVYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASNKPQEMANASLTLETPLTSKRSTTGKTSGAVWAVPPTAQGDQVPLKVLLPPAQ
  
Inhibitor
Name:
BDBM50260331
Synonyms:
CHEMBL4088230
Type:
Small organic molecule
Emp. Form.:
C28H43N5
Mol. Mass.:
449.6745
SMILES:
CC(C)N1CCN(C\C=C\c2ccc(CN(CC(C)(C)C)c3cc(C)nc(C)n3)cc2)CC1
Structure:
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