Reaction Details Report a problem with these data
Target
Transcriptional enhancer factor TEF-1
Ligand
BDBM50271259
Substrate
n/a
Meas. Tech.
ChEMBL_1710848 (CHEMBL4120897)
IC50
83±n/a nM
Citation
 Gibault, F; Sturbaut, M; Bailly, F; Melnyk, P; Cotelle, P Targeting Transcriptional Enhanced Associate Domains (TEADs). J Med Chem 61:5057-5072 (2018) [PubMed]  Article 
Target
Name:
Transcriptional enhancer factor TEF-1
Synonyms:
NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1
Type:
PROTEIN
Mol. Mass.:
47954.57
Organism:
Homo sapiens
Description:
ChEMBL_109666
Residue:
426
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
  
Inhibitor
Name:
BDBM50271259
Synonyms:
CHEMBL4129172
Type:
Small organic molecule
Emp. Form.:
C20H24N4OS
Mol. Mass.:
368.496
SMILES:
O=C(CSc1nnc[nH]1)Nc1ccc(cc1)C1C2CC3CC(C2)CC1C3 |TLB:13:16:18.25.19:23.21.22,25:24:22:18.19.20,THB:13:16:22:18.19.20,25:19:16.24.23:22,20:19:16:23.21.22,20:21:16:18.25.19,(23.85,-32.36,;23.85,-30.82,;22.52,-30.05,;21.19,-30.82,;19.85,-30.05,;19.35,-28.6,;17.81,-28.62,;17.37,-30.1,;18.63,-30.98,;25.19,-30.05,;26.52,-30.82,;26.52,-32.37,;27.85,-33.14,;29.19,-32.37,;29.18,-30.82,;27.85,-30.06,;30.52,-33.13,;31.72,-31.86,;33.05,-32.35,;34.44,-32,;34.45,-30.47,;33.06,-29.89,;31.71,-30.37,;32.02,-31.13,;32.02,-32.71,;33.43,-33.28,)|
Structure:
Search PDB for entries with ligand similarity: