Reaction Details Report a problem with these data
Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM50273615
Substrate
n/a
Meas. Tech.
ChEMBL_1713065 (CHEMBL4123114)
IC50
105000±n/a nM
Citation
 Stevenson, RJ; Azimi, I; Flanagan, JU; Inserra, M; Vetter, I; Monteith, GR; Denny, WA An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca Bioorg Med Chem 26:3406-3413 (2018) [PubMed]  Article 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM50273615
Synonyms:
CHEMBL4128236
Type:
Small organic molecule
Emp. Form.:
C19H17F3N2O3
Mol. Mass.:
378.3451
SMILES:
Cc1ccccc1C1=NN(C(=O)COc2ccccc2)C(O)(C1)C(F)(F)F |t:8|
Structure:
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