Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50455369
Substrate
n/a
Meas. Tech.
ChEMBL_1754291 (CHEMBL4189051)
EC50
4.0±n/a nM
Citation
 Harada, K; Mizukami, J; Kadowaki, S; Matsuda, I; Watanabe, T; Oe, Y; Kodama, Y; Aoki, K; Suwa, K; Fukuda, S; Yata, S; Inaba, T Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure. Bioorg Med Chem Lett 28:1228-1233 (2018) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50455369
Synonyms:
CHEMBL4203148
Type:
Small organic molecule
Emp. Form.:
C25H39NO3
Mol. Mass.:
401.5821
SMILES:
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@]3(CC(C)(C)CO3)CC2)cc1 |r,wU:18.24,15.14,(59.96,-45.11,;59.96,-46.65,;58.63,-47.41,;61.3,-47.42,;61.29,-48.96,;62.63,-46.65,;63.96,-47.42,;65.3,-46.65,;65.3,-45.1,;66.63,-44.32,;67.96,-45.09,;69.29,-44.31,;70.63,-45.08,;71.96,-44.3,;73.3,-45.07,;74.63,-44.29,;74.61,-42.75,;75.95,-41.98,;77.3,-42.75,;78.79,-43.15,;79.62,-41.85,;80.95,-41.07,;80.96,-42.62,;78.66,-40.66,;77.22,-41.21,;77.29,-44.29,;75.96,-45.06,;63.96,-44.33,;62.63,-45.1,)|
Structure:
Search PDB for entries with ligand similarity: