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Target
Peroxiredoxin-1
Ligand
BDBM50431029
Substrate
n/a
Meas. Tech.
ChEMBL_1824393 (CHEMBL4324157)
IC50
950±n/a nM
Citation
 Zhang, X; Xu, A; Lv, J; Zhang, Q; Ran, Y; Wei, C; Wu, J Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Peroxiredoxin-1
Synonyms:
1.11.1.24 | NKEF-A | Natural killer cell-enhancing factor A | PAG | PAGA | PAGB | PRDX1 | PRDX1_HUMAN | Peroxiredoxin-1 | Proliferation-associated gene protein | TDPX2 | Thioredoxin peroxidase 2 | Thioredoxin-dependent peroxide reductase 2 | Thioredoxin-dependent peroxiredoxin 1
Type:
PROTEIN
Mol. Mass.:
22114.12
Organism:
Homo sapiens
Description:
ChEMBL_100913
Residue:
199
Sequence:
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK
  
Inhibitor
Name:
BDBM50431029
Synonyms:
CHEMBL574646
Type:
Small organic molecule
Emp. Form.:
C17H15N3O
Mol. Mass.:
277.3205
SMILES:
O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1
Structure:
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