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Target
Substance-K receptor
Ligand
BDBM50051291
Substrate
n/a
Meas. Tech.
ChEMBL_209191 (CHEMBL817320)
Ki
2947±n/a nM
Citation
 Giardina, GA; Sarau, HM; Farina, C; Medhurst, AD; Grugni, M; Raveglia, LF; Schmidt, DB; Rigolio, R; Luttmann, M; Vecchietti, V; Hay, DW Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J Med Chem 40:1794-807 (1997) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50051291
Synonyms:
CHEMBL429951 | Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]-acetic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C25H20N2O3
Mol. Mass.:
396.4379
SMILES:
COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Structure:
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