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Target
Substance-P receptor
Ligand
BDBM50051291
Substrate
n/a
Meas. Tech.
ChEMBL_205882 (CHEMBL813796)
Ki
>100000±n/a nM
Citation
 Giardina, GA; Sarau, HM; Farina, C; Medhurst, AD; Grugni, M; Raveglia, LF; Schmidt, DB; Rigolio, R; Luttmann, M; Vecchietti, V; Hay, DW Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J Med Chem 40:1794-807 (1997) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50051291
Synonyms:
CHEMBL429951 | Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]-acetic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C25H20N2O3
Mol. Mass.:
396.4379
SMILES:
COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Structure:
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