Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50513383
Substrate
n/a
Meas. Tech.
ChEMBL_1853363 (CHEMBL4353987)
IC50
500±n/a nM
Citation
 Cao, F; Zwinderman, MRH; van Merkerk, R; Ettema, PE; Quax, WJ; Dekker, FJ Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages. Eur J Med Chem 177:457-466 (2019) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50513383
Synonyms:
CHEMBL4464169
Type:
Small organic molecule
Emp. Form.:
C21H21N3O
Mol. Mass.:
331.4109
SMILES:
CN(Cc1ccc(cc1)C(=O)Nc1ccccc1N)c1ccccc1
Structure:
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