Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50520865
Substrate
n/a
Meas. Tech.
ChEMBL_1882374 (CHEMBL4383873)
IC50
4.7±n/a nM
Citation
 Xing, J; Yang, L; Zhou, J; Zhang, H Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors. Bioorg Med Chem 26:5987-5999 (2018) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50520865
Synonyms:
CHEMBL4469752
Type:
Small organic molecule
Emp. Form.:
C22H21ClN4O3S
Mol. Mass.:
456.945
SMILES:
COc1ccc(NC(=O)c2nc3CCN(C)Cc3s2)c(c1)C(=O)Nc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: