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Target
Aldo-keto reductase family 1 member C2
Ligand
BDBM54706
Substrate
n/a
Meas. Tech.
ChEMBL_1925917 (CHEMBL4428989)
IC50
19040±n/a nM
Citation
 Adeniji, A; Uddin, MJ; Zang, T; Tamae, D; Wangtrakuldee, P; Marnett, LJ; Penning, TM Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. J Med Chem 59:7431-44 (2016) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member C2
Synonyms:
3-alpha-HSD3 | 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2) | AK1C2_HUMAN | AKR1C2 | Aldo-keto reductase family 1 member C2 (AK1C2) | Aldo-keto reductase family 1 member C2 (AK1C2a) | Aldo-keto reductase family 1 member C2 (AKR1C2) | Chlordecone reductase homolog HAKRD | DD-2 | DD/BABP | DDH2 | Dihydrodiol dehydrogenase 2 | Dihydrodiol dehydrogenase/bile acid-binding protein | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | Type III 3-alpha-hydroxysteroid dehydrogenase
Type:
Enzyme
Mol. Mass.:
36739.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
  
Inhibitor
Name:
BDBM54706
Synonyms:
2-(6-methoxy-2-naphthalenyl)acetic acid | 2-(6-methoxy-2-naphthyl)acetic acid | 2-(6-methoxynaphthalen-2-yl)acetic acid | 2-(6-methoxynaphthalen-2-yl)ethanoic acid | UNM-0000306103 | US11459295, Compound DesmethylNaproxen 10 | cid_32176
Type:
Small organic molecule
Emp. Form.:
C13H12O3
Mol. Mass.:
216.2326
SMILES:
COc1ccc2cc(CC(O)=O)ccc2c1
Structure:
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