Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50546584
Substrate
n/a
Meas. Tech.
ChEMBL_2016282 (CHEMBL4669860)
EC50
40±n/a nM
Citation
 Zhao, J; Chen, Z; Kusnetzow, AK; Nguyen, J; Rico-Bautista, E; Tan, H; Betz, SF; Struthers, RS; Zhu, Y Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist. Bioorg Med Chem Lett 30:127496 (2020) [PubMed] 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50546584
Synonyms:
CHEMBL4760001
Type:
Small organic molecule
Emp. Form.:
C25H27N5O2
Mol. Mass.:
429.5142
SMILES:
CN(CCN)Cc1c(cnc2ncn(-c3cccc(O)c3)c(=O)c12)-c1cc(C)cc(C)c1
Structure:
Search PDB for entries with ligand similarity: