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Target
Free fatty acid receptor 1
Ligand
BDBM168177
Substrate
n/a
Meas. Tech.
ChEMBL_2020255 (CHEMBL4674068)
EC50
9.4±n/a nM
Citation
 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Discovery of a novel potent GPR40 full agonist. Bioorg Med Chem Lett 28:720-726 (2018) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM168177
Synonyms:
US9688642, 8
Type:
Small organic molecule
Emp. Form.:
C28H29FN2O4
Mol. Mass.:
476.5393
SMILES:
[#6]-[#8]-c1ccc(F)c(c1)-c1ncc(-[#6]-[#8]-c2cccc(c2)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#6]-2-[#6]-[#6]-2)nc1\[#6]=[#6](\[#6])-[#6] |r|
Structure:
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