Reaction Details Report a problem with these data
Target
Protein argonaute-2
Ligand
BDBM50398699
Substrate
n/a
Meas. Tech.
ChEMBL_2023276 (CHEMBL4677089)
Kd
15000±n/a nM
Citation
 Kitamura, Y; Kandeel, M; Kondo, T; Tanaka, A; Makino, Y; Miyamoto, N; Shibata, A; Ikeda, M; Kitade, Y Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Protein argonaute-2
Synonyms:
3.1.26.n2 | AGO2 | AGO2_HUMAN | Argonaute RISC catalytic component 2 | Argonaute2 | EIF2C2 | Eukaryotic translation initiation factor 2C 2 | PAZ Piwi domain protein | PPD | Protein argonaute-2 | Protein slicer | eIF-2C 2 | eIF2C 2 | hAgo2
Type:
PROTEIN
Mol. Mass.:
97253.38
Organism:
Homo sapiens
Description:
ChEMBL_120111
Residue:
859
Sequence:
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA
  
Inhibitor
Name:
BDBM50398699
Synonyms:
CHEMBL214393
Type:
Small organic molecule
Emp. Form.:
C9H13N2O9P
Mol. Mass.:
324.1813
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
Search PDB for entries with ligand similarity: