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Target
Thymidylate kinase
Ligand
BDBM50550239
Substrate
n/a
Meas. Tech.
ChEMBL_2027165 (CHEMBL4681323)
IC50
470±n/a nM
Citation
 Chen, YH; Hsu, HY; Yeh, MT; Chen, CC; Huang, CY; Chung, YH; Chang, ZF; Kuo, WC; Chan, NL; Weng, JH; Chung, BC; Chen, YJ; Jian, CB; Shen, CC; Tai, HC; Sheu, SY; Fang, JM Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation. J Med Chem 59:9906-9918 (2016) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
CDC8 | DTYMK | KTHY_HUMAN | TMPK | TYMK
Type:
PROTEIN
Mol. Mass.:
23824.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_946051
Residue:
212
Sequence:
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
  
Inhibitor
Name:
BDBM50550239
Synonyms:
CHEMBL4758532
Type:
Small organic molecule
Emp. Form.:
C17H22N4O4S
Mol. Mass.:
378.446
SMILES:
CC(C)(C)OC(=O)N1CCN(CC1)C(=O)Cn1sc2ncccc2c1=O
Structure:
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