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Target
Genome polyprotein
Ligand
BDBM50111456
Substrate
n/a
Meas. Tech.
ChEMBL_158809 (CHEMBL765657)
EC50
111±n/a nM
Citation
Dragovich, PS; Prins, TJ; Zhou, R; Brown, EL; Maldonado, FC; Fuhrman, SA; Zalman, LS; Tuntland, T; Lee, CA; Patick, AK; Matthews, DA; Hendrickson, TF; Kosa, MB; Liu, B; Batugo, MR; Gleeson, JP; Sakata, SK; Chen, L; Guzman, MC; Meador, JW; Ferre, RA; Worland, ST Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. J Med Chem 45:1607-23 (2002) [PubMed] Article
More Info.:
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
Inhibitor
Name:
BDBM50111456
Synonyms:
4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-(4-fluoro-phenyl)-propionylamino]-6-carbamoyl-hex-2-enoic acid ethyl ester | CHEMBL44129 | trans-(2'S,4S)-4-[2'-(3''-Benzyloxycarbonylamino-2''-oxo-2''H-pyridin-1''-yl)-3'-(4'''-fluorophenyl)propionylamino]-6-carbamoylhex-2-enoic Acid Ethyl Ester
Type:
Small organic molecule
Emp. Form.:
C31H33FN4O7
Mol. Mass.:
592.6147
SMILES:
CCOC(=O)\C=C\[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(F)cc1)n1cccc(NC(=O)OCc2ccccc2)c1=O |r|