Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM50557820
Substrate
n/a
Meas. Tech.
ChEMBL_2060190 (CHEMBL4715191)
IC50
305±n/a nM
Citation
 Che, J; Wang, Z; Shen, Z; Zhuang, W; Ying, H; Hu, Y; Hu, Y; Xie, X; Dong, X Discovery of 1,5-Dihydro-4 ACS Med Chem Lett 12:836-845 (2021) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50557820
Synonyms:
CHEMBL4799848
Type:
Small organic molecule
Emp. Form.:
C18H17Cl2N3O4S
Mol. Mass.:
442.316
SMILES:
CC(C)S(=O)(=O)c1c(Cl)ccc(NC2=NC(=O)C(N2)c2cccc(Cl)c2)c1O |t:13|
Structure:
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