Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50125024
Substrate
n/a
Meas. Tech.
ChEBML_69678
IC50
307±n/a nM
Citation
Su, T; Yang, H; Volkots, D; Woolfrey, J; Dam, S; Wong, P; Sinha, U; Scarborough, RM; Zhu, BY Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors. Bioorg Med Chem Lett 13:729-32 (2003) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50125024
Synonyms:
2-[(S)-3-(3-Guanidino-propyl)-2-oxo-3,4-dihydro-2H-pyrazin-1-yl]-N-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide | CHEMBL163527
Type:
Small organic molecule
Emp. Form.:
C19H30N10O3S
Mol. Mass.:
478.572
SMILES:
NC(=N)NCCC[C@H](NC(=O)CN1CC=N[C@@H](CCCNC(N)=N)C1=O)C(=O)c1nccs1 |c:14|