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Target
D(2) dopamine receptor
Ligand
BDBM50026553
Substrate
n/a
Meas. Tech.
ChEMBL_59906 (CHEMBL671065)
EC50
0.7±n/a nM
Citation
 Venhuis, BJ; Dijkstra, D; Wustrow, D; Meltzer, LT; Wise, LD; Johnson, SJ; Wikström, HV Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity. J Med Chem 46:4136-40 (2003) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50026553
Synonyms:
(+)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol | (+/-)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol | (-)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol (DP-5,6-ADTN) | CHEMBL11845
Type:
Small organic molecule
Emp. Form.:
C16H25NO2
Mol. Mass.:
263.3752
SMILES:
CCCN(CCC)C1CCc2c(C1)ccc(O)c2O
Structure:
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