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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50150565
Substrate
n/a
Meas. Tech.
ChEMBL_306397 (CHEMBL828738)
IC50
8900±n/a nM
Citation
 Weidner-Wells, MA; Henninger, TC; Fraga-Spano, SA; Boggs, CM; Matheis, M; Ritchie, DM; Argentieri, DC; Wachter, MP; Hlasta, DJ Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists. Bioorg Med Chem Lett 14:4307-11 (2004) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50150565
Synonyms:
1-(2-{4-[5-(4-Chloro-phenyl)-isoxazol-3-yl]-phenoxy}-ethyl)-4-methyl-piperazine | CHEMBL185476
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O2
Mol. Mass.:
397.898
SMILES:
CN1CCN(CCOc2ccc(cc2)-c2cc(on2)-c2ccc(Cl)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: