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Target
Cathepsin K
Ligand
BDBM50163831
Substrate
n/a
Meas. Tech.
ChEMBL_306044 (CHEMBL833001)
IC50
0.048000±n/a nM
Citation
 Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Shewchuk, LM; Tavares, FX; Willard, DH; Wright, LL Novel and potent cyclic cyanamide-based cathepsin K inhibitors. Bioorg Med Chem Lett 15:1815-9 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50163831
Synonyms:
(2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-carboxylate | CHEMBL183812
Type:
Small organic molecule
Emp. Form.:
C14H22N2O2
Mol. Mass.:
250.3367
SMILES:
C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N
Structure:
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