Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50184358
Substrate
n/a
Meas. Tech.
ChEMBL_338134 (CHEMBL867662)
IC50
>10000±n/a nM
Citation
 Mayorov, AV; Cai, M; Chandler, KB; Petrov, RR; Van Scoy, AR; Yu, Z; Tanaka, DK; Trivedi, D; Hruby, VJ Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem 49:1946-52 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
  
Inhibitor
Name:
BDBM50184358
Synonyms:
CHEMBL203170 | c[Nle-Asp-D-Phe-Arg-Trp-Glu]-NH2
Type:
Small organic molecule
Emp. Form.:
C41H55N11O9
Mol. Mass.:
845.9437
SMILES:
CCCC[C@@H]1NC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC1=O)C(N)=O |wU:10.61,39.41,wD:28.30,50.53,14.14,4.3,(-1.81,3.94,;-1.8,2.4,;-.71,1.68,;-.72,.16,;.5,-.54,;2.21,.09,;2.2,1.63,;.87,2.39,;3.42,2.4,;3.94,3.69,;5.46,3.9,;6.23,2.56,;6.99,1.23,;8.48,1.64,;7.39,-.26,;8.93,-.26,;9.7,-1.6,;9.69,-3.14,;11.16,-3.62,;12.06,-2.38,;13.59,-2.23,;14.23,-.83,;13.33,.43,;11.8,.27,;11.17,-1.12,;6.45,-1.47,;7.04,-2.9,;8.58,-2.89,;6.63,-4.38,;7.72,-5.47,;9.21,-5.07,;10.3,-6.16,;11.79,-5.76,;12.88,-6.85,;14.37,-6.46,;12.48,-8.34,;5.29,-5.14,;3.97,-4.36,;3.98,-2.82,;2.63,-5.13,;2.62,-6.67,;3.96,-7.44,;3.95,-8.98,;5.28,-9.76,;6.62,-8.99,;6.61,-7.44,;5.28,-6.68,;1.29,-4.35,;-.04,-5.12,;-.04,-6.65,;-1.37,-4.35,;-2.56,-5.1,;-3.79,-4.45,;-3.84,-3.05,;-4.97,-5.19,;-1.37,-2.82,;.16,-2.06,;1.39,-2.81,;6.24,5.23,;5.47,6.57,;7.78,5.23,)|
Structure:
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