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Target
Metabotropic glutamate receptor 7
Ligand
BDBM50610110
Substrate
n/a
Meas. Tech.
ChEMBL_2280172
EC50
1200±n/a nM
Citation
 Kalbfleisch, JJ; Rodriguez, AL; Lei, X; Weiss, K; Blobaum, AL; Boutaud, O; Niswender, CM; Lindsley, CW Persistent challenges in the development of an mGlu Bioorg Med Chem Lett 80:0 (2023) [PubMed] 
Target
Name:
Metabotropic glutamate receptor 7
Synonyms:
GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7
Type:
Enzyme
Mol. Mass.:
102244.48
Organism:
Rattus norvegicus (Rat)
Description:
P35400
Residue:
915
Sequence:
MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
  
Inhibitor
Name:
BDBM50610110
Synonyms:
CHEMBL5288733
Type:
Small organic molecule
Emp. Form.:
C21H17FN6O2
Mol. Mass.:
404.3971
SMILES:
COc1cc(F)cc2c(N3CCN4C(C3)C(=O)Nc3ccccc43)c(nnc12)C#N
Structure:
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