Reaction Details Report a problem with these data
Target
m7GpppX diphosphatase
Ligand
BDBM50613666
Substrate
n/a
Meas. Tech.
ChEMBL_2292815
IC50
36±n/a nM
Citation
 Calder, AN; Androphy, EJ; Hodgetts, KJ Small Molecules in Development for the Treatment of Spinal Muscular Atrophy. J Med Chem 59:10067-10083 (2016) [PubMed] 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Homo sapiens (Human)
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM50613666
Synonyms:
CHEMBL4085817
Type:
Small organic molecule
Emp. Form.:
C21H22IN5O2
Mol. Mass.:
501.3363
SMILES:
Nc1nc(N)c2c(OCC3CCN(CC3)C(=O)c3cccc([125I])c3)cccc2n1
Structure:
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