Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50203613
Substrate
n/a
Meas. Tech.
ChEMBL_454261 (CHEMBL903444)
Ki
570±n/a nM
Citation
 Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett 17:2026-30 (2007) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50203613
Synonyms:
CHEMBL245297 | [8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-methyl-(2-pyridin-3-yl-ethyl)-amine
Type:
Small organic molecule
Emp. Form.:
C26H27ClN6
Mol. Mass.:
458.986
SMILES:
CN(CCc1cccnc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 |(-9.05,.26,;-8.05,-.9,;-6.54,-.64,;-6.01,.8,;-7,1.99,;-8.51,1.71,;-9.49,2.89,;-8.96,4.34,;-7.44,4.61,;-6.46,3.42,;-8.58,-2.35,;-7.59,-3.53,;-7.96,-5.02,;-9.38,-5.6,;-6.65,-5.84,;-5.47,-4.85,;-3.93,-4.74,;-2.94,-5.92,;-1.44,-5.65,;-.91,-4.2,;-.44,-6.82,;-.97,-8.28,;.02,-9.46,;-2.49,-8.55,;-3.48,-7.37,;-4.99,-7.63,;-3.56,-3.25,;-2.19,-2.53,;-2.13,-.98,;-3.51,-.09,;-4.81,-.89,;-4.87,-2.43,;-6.05,-3.42,)|
Structure:
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