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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50134840
Substrate
n/a
Meas. Tech.
ChEMBL_447651 (CHEMBL896658)
EC50
6400±n/a nM
Citation
 Havranek, M; Sauerberg, P; Mogensen, JP; Kratina, P; Jeppesen, CB; Pettersson, I; Pihera, P Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety. Bioorg Med Chem Lett 17:4144-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50134840
Synonyms:
(S)-2-Ethoxy-3-[4-((E)-5-phenyl-pent-2-en-4-ynyloxy)-phenyl]-propionic acid | (S)-2-ethoxy-3-(4-(5-phenylpent-2-en-4-ynyloxy)phenyl)propanoic acid | CHEMBL446893
Type:
Small organic molecule
Emp. Form.:
C22H22O4
Mol. Mass.:
350.4077
SMILES:
CCO[C@@H](Cc1ccc(OC\C=C\C#Cc2ccccc2)cc1)C(O)=O
Structure:
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