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Target
Dipeptidyl peptidase 2
Ligand
BDBM50215340
Substrate
n/a
Meas. Tech.
ChEMBL_439393 (CHEMBL888508)
IC50
33000±n/a nM
Citation
 Cox, JM; Harper, B; Mastracchio, A; Leiting, B; Sinha Roy, R; Patel, RA; Wu, JK; Lyons, KA; He, H; Xu, S; Zhu, B; Thornberry, NA; Weber, AE; Edmondson, SD Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 17:4579-83 (2007) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:
Protein
Mol. Mass.:
54339.29
Organism:
Homo sapiens (Human)
Description:
Q9UHL4
Residue:
492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
  
Inhibitor
Name:
BDBM50215340
Synonyms:
(3R,4R)-1-(pyrazin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium 2,2,2-trifluoroacetate | CHEMBL230985
Type:
Small organic molecule
Emp. Form.:
C15H16F3N4
Mol. Mass.:
309.309
SMILES:
[NH3+][C@H]1CN(CC[C@@H]1c1cc(F)c(F)cc1F)c1cnccn1
Structure:
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