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Target
Coagulation factor X
Ligand
BDBM50224701
Substrate
n/a
Meas. Tech.
ChEMBL_458333 (CHEMBL941667)
Ki
500±n/a nM
Citation
 Varnes, JG; Wacker, DA; Jacobson, IC; Quan, ML; Ellis, CD; Rossi, KA; He, MY; Luettgen, JM; Knabb, RM; Bai, S; He, K; Lam, PY; Wexler, RR Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors. Bioorg Med Chem Lett 17:6481-8 (2007) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50224701
Synonyms:
1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl)-6-(2-(methylsulfonyl)phenyl)-2,3-dihydroquinolin-4(1H)-one | CHEMBL398517
Type:
Small organic molecule
Emp. Form.:
C28H20F3N5O5S
Mol. Mass.:
595.549
SMILES:
CS(=O)(=O)c1ccccc1-c1ccc2N(CCC(=O)c2c1)C(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F
Structure:
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