Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 4
Ligand
BDBM50307029
Substrate
n/a
Meas. Tech.
ChEMBL_609338 (CHEMBL1072093)
IC50
2560±n/a nM
Citation
 Li, G; Wang, D; Sun, M; Li, G; Hu, J; Zhang, Y; Yuan, Y; Ji, H; Chen, N; Liu, G Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. J Med Chem 53:1741-54 (2010) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50307029
Synonyms:
CHEMBL601217 | N-(4-(4-(5,7-Dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)-piperazin-1-ylsulfonyl)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C22H23N3O7S
Mol. Mass.:
473.499
SMILES:
CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1c(C)c2c(O)cc(O)cc2oc1=O
Structure:
Search PDB for entries with ligand similarity: