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Target
Histone deacetylase 8
Ligand
BDBM50349223
Substrate
n/a
Meas. Tech.
ChEMBL_759734 (CHEMBL1811683)
IC50
86±n/a nM
Citation
 Zhang, Y; Feng, J; Liu, C; Fang, H; Xu, W Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors. Bioorg Med Chem 19:4437-44 (2011) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50349223
Synonyms:
CHEMBL1808379
Type:
Small organic molecule
Emp. Form.:
C28H31N3O6
Mol. Mass.:
505.5622
SMILES:
COc1ccc(NC(=O)[C@H](Cc2ccc(OCC(=O)NO)cc2)NC(=O)CCCc2ccccc2)cc1 |r|
Structure:
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