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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM50359739
Substrate
n/a
Meas. Tech.
ChEMBL_792520 (CHEMBL1929950)
IC50
1800±n/a nM
Citation
 Redondo, M; Zarruk, JG; Ceballos, P; Pérez, DI; Pérez, C; Perez-Castillo, A; Moro, MA; Brea, J; Val, C; Cadavid, MI; Loza, MI; Campillo, NE; Martínez, A; Gil, C Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Eur J Med Chem 47:175-85 (2012) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM50359739
Synonyms:
CHEMBL1927730
Type:
Small organic molecule
Emp. Form.:
C14H8BrClN2OS
Mol. Mass.:
367.648
SMILES:
Clc1cccc2c1[nH]c(=S)n(-c1ccccc1Br)c2=O |(7.12,-23.52,;7.13,-21.98,;5.79,-21.21,;5.8,-19.67,;7.12,-18.9,;8.46,-19.66,;8.46,-21.22,;9.81,-21.99,;11.15,-21.21,;12.48,-21.97,;11.14,-19.65,;12.47,-18.88,;13.81,-19.65,;15.14,-18.88,;15.13,-17.34,;13.79,-16.57,;12.46,-17.35,;11.13,-16.59,;9.79,-18.88,;9.78,-17.34,)|
Structure:
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