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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50361772
Substrate
n/a
Meas. Tech.
ChEMBL_799449 (CHEMBL1942257)
IC50
1.7±n/a nM
Citation
 Graham, TH; Shen, HC; Liu, W; Xiong, Y; Verras, A; Bleasby, K; Bhatt, UR; Chabin, RM; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Lassman, ME; Shen, Z; Tong, X; Tung, EC; Xie, D; Xu, S; Colletti, SL; Tata, JR; Hale, JJ; Pinto, S; Shen, DM The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett 22:658-65 (2011) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50361772
Synonyms:
CHEMBL1938508
Type:
Small organic molecule
Emp. Form.:
C28H29ClF3N3O2
Mol. Mass.:
531.997
SMILES:
C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)NC(c1ccc(Cl)cc1)C(F)(F)F)c1ccc(cc1)-c1ccccc1 |r|
Structure:
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