Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50134840
Substrate
n/a
Meas. Tech.
ChEMBL_456458 (CHEMBL887279)
EC50
2600±n/a nM
Citation
 Pettersson, I; Ebdrup, S; Havranek, M; Pihera, P; Korínek, M; Mogensen, JP; Jeppesen, CB; Johansson, E; Sauerberg, P Design of a partial PPARdelta agonist. Bioorg Med Chem Lett 17:4625-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50134840
Synonyms:
(S)-2-Ethoxy-3-[4-((E)-5-phenyl-pent-2-en-4-ynyloxy)-phenyl]-propionic acid | (S)-2-ethoxy-3-(4-(5-phenylpent-2-en-4-ynyloxy)phenyl)propanoic acid | CHEMBL446893
Type:
Small organic molecule
Emp. Form.:
C22H22O4
Mol. Mass.:
350.4077
SMILES:
CCO[C@@H](Cc1ccc(OC\C=C\C#Cc2ccccc2)cc1)C(O)=O
Structure:
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