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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50304006
Substrate
n/a
Meas. Tech.
ChEMBL_595421 (CHEMBL1040062)
Ki
>1000±n/a nM
Citation
 de la Fuente, T; Martín-Fontecha, M; Sallander, J; Benhamú, B; Campillo, M; Medina, RA; Pellissier, LP; Claeysen, S; Dumuis, A; Pardo, L; López-Rodríguez, ML Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. J Med Chem 53:1357-69 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50304006
Synonyms:
5-(4-Methylpiperazin-1-yl)-2-(2-naphthylmethyl)-1H-benzimidazole | CHEMBL565350
Type:
Small organic molecule
Emp. Form.:
C23H24N4
Mol. Mass.:
356.4635
SMILES:
CN1CCN(CC1)c1ccc2nc(Cc3ccc4ccccc4c3)[nH]c2c1
Structure:
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